However, considering that mitochondrial dysfunction is associated with numerous neurodegenerative diseases ( Pathak et al, 2013 Sheng & Cai, 2012), determining if and when bioenergetic failure in distal axons contributes to neuronal pathology is highly clinically relevant. Precisely how neurons sense and respond to dynamic changes in energy demand during rest, activation, growth, and in pathological conditions is still being elucidated ( Sheng, 2017). As ATP diffusion is not effective over the long distances of neuronal processes ( Hubley et al, 1996 Sun et al, 2013), neurons require specialized mechanisms to maintain energy homeostasis throughout the cell, particularly in distal axons that can extend several centimeters to several feet long for some peripheral nerves ( Saxton & Hollenbeck, 2012). These substrates are metabolized to generate adenosine triphosphate (ATP), the primary energy currency for all living organisms. Energy substrates, such as glucose, ketone bodies, and lactate ( Camandola & Mattson, 2017), are supplied to the brain via adaptive changes in blood flow ( Ogawa et al, 1992). Action potentials, maintenance of ionic gradients, organelle transport, neurotransmitter uptake, synaptic vesicle recycling, and axonal growth require continual energy production within the brain.
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Considering the elaborate structure and function of neural circuitry, it is not surprising that the brain consumes ~20-25% of our daily energy budget ( Herculano-Houzel, 2012 Mink et al, 1981 Rolfe & Brown, 1997).
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#Integrity plus pool supply license#
We hold a California contractor’s license (249712).We have continued to grow as a family-owned business for over 52 years.We believe that good citizenship is the cornerstone of our INTEGRITY.We even keep an over-supply of service vehicles to make sure we never let you down.15 of our managers and technicians have been with Swim Chem for 15 years or more. Not only do we have 30+ technicians on routes Monday through Friday, we also have 5 managers on the road, ready to respond to customers or technicians with any unusual circumstances.If a spring/summer holiday falls on your service day, don’t worry.GREAT SERVICE means no worries for you.We are really good at what we do because we know what we are doing.
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#Integrity plus pool supply how to#
Most importantly, we know how to be proactive in keeping the water in your pool within all acceptable chemical ranges.We know how weather causes changes in the chemical makeup of pool water.Our managers and technicians are trained to know how various chemicals interact with different water conditions.Without the proper scientific knowledge, we cannot maintain your investment or our INTEGRITY.SCIENCE is at the core of the SERVICE we provide.It’s about SCIENCE, SERVICE, and INTEGRITY.